Detection of type-specific antibody to lymphogranuloma venereum serotypes ofChlamydia trachomatis with a microneutralization test |
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| Authors: | Stella Pardini Ronald C Ballard |
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| Institution: | (1) Emergent Pathogen Research Unit of the South African Research Council, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, Post Office Box 1038, 2000 Johannesburg, South Africa |
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| Abstract: | Ten-day monospecific mouse antisera prepared against serotypes L1, L2, and L3 ofChlamydia trachomatis were titrated against homologous and heterologous antigens in the microimmunofluorescence (micro-IF) test and by a new microneutralization method. While broad crossreactivity between serotypes was detected in the micro-IF test, the same antisera demonstrated serotype specific neutralizing activity. The microneutralization test could be used for serotyping new chlamydial isolates when equivocal results have been obtained by the microimmunofluorescence method. |
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