Acute toxicity of prostaglandins E2,F2α and 15 (s) 15 methyl prostaglandin E2 methyl ester in the baboon |
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| Authors: | P Adaikan Ganesan S M M Karim |
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| Institution: | Department of Obstetrics and Gynaecology, University of Singapore, Kandang Kerbau Hospital, Singapore 8 |
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| Abstract: | The cardiovascular, uterine stimulant and gastrointestinal effects of prostaglandins E2, F2α and 15 (S) 15 methyl PGE2 methyl ester in the East African Baboon (P. Anubis) have been studied. In these three parameters the baboon responds both qualitatively and quantitatively in a similar manner to man. The lethal doses of the prostaglandins given by bolus intravenous injelctions have been determined and the human lethal doses estimated. |
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