Effect of Ca2+ on the self assembly of a nonionic peptide aggregate |
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| Authors: | Moses Julia P. Inayathullah N. Mohammed Murugesan Muthu Andrews Maneesha E. Balasubramanian M. P. Jayakumar Rajadas |
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| Affiliation: | (1) Bioorganic Laboratory, Central Leather Research Institute, Adyar, Chennai, India;(2) Department of Pharmacology & Environment Toxicology, ALMPGIBMS, University of Madras, Taramani, India |
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| Abstract: | Summary Conductometry, circular dichroism and fluorescence spectroscopy are the techniques employed to investigate the effect of added calcium ions and other monovalent and divalent metal ions on aqueous solutions of nonionic peptide aggregates, Boc-Leu-Asn-OEt (1). It is observed that among all the metal ions studied, Ca2+ ions facilitate the aggregation of the peptide. The interior dielectric constant of the micelles (ε) was found to depend upon the proportion of Ca2+ complexed peptide with the peptide mononers in the micelles. When Ca2+ ion becomes 1/4th of the peptide concentration, there is a structural transition leading to drastic change in the interior of the micro dielectric constant (ɛ m). |
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| Keywords: | calcium ions peptide self-assembly |
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