Bioactive marine prostanoids from octocoral Clavularia viridis |
| |
| Authors: | Lin Yun-Sheng Khalil Ashraf Taha Chiou Shih-Hwa Kuo Yuh-Chi Cheng Yuan-Bin Liaw Chia-Ching Shen Ya-Ching |
| |
| Affiliation: | Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, Republic of China. |
| |
| Abstract: | Chemical investigation of the nonpolar extract of soft coral Clavularia viridis resulted in isolation of five new prostanoids, designated as claviridic acids A-E (1-5, resp.), in addition to the known clavulones I-III. Their structures were determined on the basis of spectroscopic techniques, especially HR-ESI-MS, CD, and 2D-NMR experiments. The isolated marine prostanoids exhibited potent inhibitory effect on PHA-induced proliferation of peripheral blood mononuclear cells (PBMC), as well as significant cytotoxic activity against human gastric cancer cells (AGS). |
| |
| Keywords: | Prostanoids Claviridic acids A – E Clavulones I – III Clavularia viridis Cytotoxic activity Antiproliferating activity |
| 本文献已被 PubMed 等数据库收录！ |
|
