Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi |
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Authors: | Nora Khaldi Jérôme Collemare Marc-Henri Lebrun Kenneth H Wolfe |
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Institution: | Nora Khaldi, Jérôme Collemare, Marc-Henri Lebrun, and Kenneth H Wolfe |
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Abstract: | Background Filamentous fungi synthesize many secondary metabolites and are rich in genes encoding proteins involved in their biosynthesis.
Genes from the same pathway are often clustered and co-expressed in particular conditions. Such secondary metabolism gene
clusters evolve rapidly through multiple rearrangements, duplications and losses. It has long been suspected that clusters
can be transferred horizontally between species, but few concrete examples have been described so far. |
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