Persistence of two Y chromosomes through meiotic prophase and metaphase I in an XYY man |
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| Authors: | R. M. Speed M. J. W. Faed P. J. Batstone K. Baxby W. Barnetson |
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| Affiliation: | (1) MRC Human Genetics Unit, Western General Hospital, EH4 2XU Edinburgh, UK;(2) Human Genetics Section, Department of Pathology, University of Dundee, Dundee, UK;(3) Histopathology Section, Department of Pathology, University of Dundee, Dundee, UK;(4) Department of Surgery, University of Dundee, Dundee, UK |
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| Abstract: | Summary Studies of spermatogenesis in an XYY male, presenting at a subfertility clinic, confirm the tendency for the germ cells to lose the second Y chromosome but for some XYY cells to reach metaphase I (MI). Light microscope studies of MI revealed the presence of YY bivalents and EM studies of microspread, silver-stained pachytene stages showed 30% of the cells to have two Y chromosomes; 13 out of 16 of these showing a YY synaptonemal complex. Strikingly, the Y axes show only partial synapsis; in no case was synapsis of the long arm heterochromatic regions apparent. |
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