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Recent developments on the regulation and structure of glutamine synthetase enzymes from selected bacterial groups
Authors:David R. Woods  Sharon J. Reid
Affiliation:Department of Microbiology, University of Cape Town, Rondebosch, South Africa
Abstract:Abstract: The structure of glutamine synthetase (GS) enzymes from diverse bacterial groups fall into three distinct classes. GSI is the typical bacterial GS, GSII is similar to the eukaryotic GS and is found together with GSI in plant symbionts and Streptomyces , while GSIII has been found in two unrelated anaerobic rumen bacteria. In most cases, the structural gene for GS enzyme is regulated in response to nitrogen. However, different regulatory mechanisms, to ensure optimal utilization of nitrogen substrates, control the GS enzyme in each class.
Keywords:Glutamine synthetase    Nitrogen metabolism    Glutamine    Amino acid biosynthesis
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