Sequential monitoring of randomization tests: stratified randomization |
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Authors: | Zhang Yanqiong Rosenberger William F Smythe Robert T |
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Affiliation: | Merck & Co., Ry34-A316, P.O. Box 2000, Rahway, New Jersey 07065-0900, USA. yanqiong_zhang@merck.com |
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Abstract: | In many clinical trials, it is desirable to establish a sequential monitoring plan, whereby the test statistic is computed at an interim point or points in the trial and a decision is made whether to stop early due to evidence of treatment efficacy. In this article, we will set up a sequential monitoring plan for randomization-based inference under the permuted block design, stratified block design, and stratified urn design. We will also propose a definition of information fraction in these settings and discuss its calculation under these different designs. |
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Keywords: | Information fraction Linear rank tests Permutation tests Permuted block design Stratified block design Stratified urn design |
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