Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models |
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| Authors: | O. Wirths T. A. Bayer |
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| Affiliation: | Division of Molecular Psychiatry, Department of Psychiatry, University of Goettingen, Goettingen, Germany |
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| Abstract: | In this commentary, we accent the accumulating evidence for motor impairment as a common feature of early Alzheimer's disease (AD) pathology. In addition, we summarize the state of knowledge on this phenotype in experimental mouse models, expressing AD-associated genes like tau or amyloid precursor protein. |
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| Keywords: | Alzheimer's disease amyloid APP axonal transport intracellular Aβ motor impairment tau |
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