Production of macrolide antibiotics from a cytotoxic soil Streptomyces sp. strain ZDB |
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Authors: | Zerihun T. Dame Pornthip Ruanpanun |
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Affiliation: | 1.Department of Biology, College of Natural and Computational Science,Ambo University,Ambo,Ethiopia;2.Department of Plant Pathology, Faculty of Agriculture at Kamphaeng Saen,Kasetsart University,Nakhon Pathom,Thailand |
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Abstract: | Crude extract from a culture of a soil Streptomyces sp. strain ZDB showed toxicity towards Artemia salina and antimicrobial activity against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Chlorella vulgaris, and Chlorella sorokiniana. Large scale fermentation of the strain led to the isolation of the macrolide antibiotics, bafilomycins A1 (1), B1 (2), and D (3) together with nonactic acid (4) and bostrycoidin-9-methyl ether (5). Structures of the antibiotics were determined based on spectral data analysis. We describe the isolation of the compounds and characterization of the producing strain. |
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