| Affiliation: | (1) MRC Dunn Human Nutrition Unit, Hills Road, CB2 2XY Cambridge, UK;(2) Department of Chemistry, University of Otago, Box 56, Dunedin, New Zealand;(3) Pharmaceutical Science Department, Trieste University, 34127 Trieste, Italy |
| Abstract: | Lipophilic phosphonium cations were first used to investigate mitochondrial biology by Vladimir Skulachev and colleagues in the late 1960s. Since then, these molecules have become important tools for exploring mitochondrial bioenergetics and free radical biology. Here we review why these molecules are useful in mitochondrial research and outline some of the ways in which they are now being utilized.Translated from Biokhimiya, Vol. 70, No. 2, 2005, pp. 273–283.Original Russian Text Copyright ¢ 2005 by Ross, Kelso, Blaikie, James, Cochemé, Filipovska, Da Ros, Hurd, Smith, Murphy.This revised version was published online in April 2005 with corrections to the post codes. |
