Regioselective acylation of flavonoids catalyzed by immobilized Candida antarctica lipase under reduced pressure |
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Authors: | Emilie Passicos Xavier Santarelli Denis Coulon |
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Affiliation: | Ecole Supérieure de Technologie des Biomolécules de Bordeaux, Université Victor Segalen Bordeaux2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France. |
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Abstract: | A single-step acylation of rutin and naringin, catalyzed by immobilized Candida antarctica lipase B in 2-methyl-2-butanol, occurred preferentially on the primary hydroxyl group. Using palmitic methyl ester as acyl donor, the acylation rate of naringin was 10-fold higher than that of rutin. Under optimal conditions, i.e. a molar ratio acyl donor/naringin of 7:1 and 200 mbar, 92% naringin was acylated. |
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Keywords: | Candida antarctica lipase flavonoid ester molar ratio reduced pressure transesterification |
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