EFFECT OF DIBUTYRYL-CYCLIC AMP and DEXAMETHASONE ON NORADRENALINE SYNTHESIS IN ISOLATED SUPERIOR CERVICAL GANGLIA |
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Authors: | P. Keen W. G. McLean |
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Affiliation: | Department of Pharmacology. The Medical School, University of Bristol. Bristol. U.K. |
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Abstract: | Abstract— Incubation with dibutyryl-cyclic AMP increased levels of both noradrenaline and dopamine- β -hydroxylase in isolated rat superior cervical ganglia. Dexamethasone also increased the dopamine- β -hydroxylase content but did not affect noradrenaline levels. Cycloheximide blocked the effect of dibutyryl-cyclic AMP on ganglion dopamine- β -hydroxylase but did not affect the rise in noradrenaline content. Dibutyryl-cyclic AMP increased the synthesis of noradrenaline from [14C]tyrosine but not from [3H]DOPA. The results are discussed in terms of a possible role for cyclic AMP in the control of noradrenaline synthesis in sympathetic ganglia. |
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