Tissue-specific and differential expression of prothymosin alpha gene during rat development. |
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| Authors: | M Dosil M Freire J Gómez-Márquez |
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| Institution: | Departamento de Bioquimica e Bioloxia Molecular, Facultade de Bioloxia, Universidade de Santiago, Santiago de Compostela, Galicia, Spain. |
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| Abstract: | We have analyzed the RNA expression of prothymosin alpha (ProT alpha) gene during rat development in several tissues and compared it to that of two proteins related to cell proliferation: proliferating cell nuclear antigen (PCNA)/cyclin and histone H3 (H3). The expression of ProT alpha gene was found to be regulated in a developmental and tissue-specific manner. The mRNA levels of ProT alpha followed a similar time-course in liver, brain, kidney, and testis, being highly increased in the early periods of postnatal development. However, in thymus ProT alpha mRNA showed only moderate changes throughout development. Our findings suggest that ProT alpha participates in developmental processes like cell proliferation and/or differentiation. |
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