A new inhibitor of the long-chain fatty acid transfer across the mitochondrial membrane: 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304) |
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| Authors: | F H Schmidt I V Deaciuc H F Kuhnle |
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| Affiliation: | 1. Boehringer Mannheim GmbH, Medizinische Forschung, Stoffwechsel, D-6800 Mannheim, F.R.G.;7. Louisiana State University Medical Center, Department of Physiology, New Orleans, LA 70112, USA |
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| Abstract: | Using two different assay systems to distinguish between overt and inner forms of carnitine palmitoyl transferase (CPT, EC 2.3.1.21) of intact guinea-pig liver mitochondria, we have shown that the hypoglycemic agent 2-(3-methylcinnamylhydrazono)-propionate (BM 42.304) inhibits the activity of carnitine-acylcarnitine translocase of liver mitochondria. The results offer an explanation for the inhibitory effect of the compound on ketogenesis with oleate but not with octanoate in the perfused guinea-pig liver, previously reported by us (Biochem. Pharmacol. 32, 3405-3412, 1983). |
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| Keywords: | To whom correspondence and reprint requests should be addressed. |
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