| mTOR与S6K在衰老进程中的作用 |
| |
| 引用本文： | 朱枫,马利伟,童坦君.mTOR与S6K在衰老进程中的作用[J].生物化学与生物物理进展,2014,41(5):443-448. |
| |
| 作者姓名： | 朱枫 马利伟 童坦君 |
| |
| 作者单位： | 北京大学医学部基础医学院生物化学与分子生物学系，北京大学衰老研究中心，北京 100191,北京大学医学部基础医学院生物化学与分子生物学系，北京大学衰老研究中心，北京 100191,北京大学医学部基础医学院生物化学与分子生物学系，北京大学衰老研究中心，北京 100191 |
| |
| 基金项目： | 北京高等学校青年英才计划项目(YETP0057)和国家重点基础研究发展计划(2013CB530801)资助项目 |
| |
| 摘 要： | 衰老进程受到多个基因以及信号通路的调节.哺乳动物雷帕霉素靶蛋白mTOR与核糖体S6K蛋白激酶不仅调节细胞的多种生理功能,在衰老进程中也发挥着重要作用.最近的实验表明,抑制mTORC1或S6K的活性可以延长小鼠的寿限.mTOR通路通过多种方式在衰老进程中发挥作用,包括细胞自噬、代谢副产物的积累以及影响组织干细胞的数量等等.而S6K在衰老进程中的作用并不十分清晰.目前mTOR和S6K已成为研究热点,通过对这两个分子在衰老进程中作用的研究,有望找到延长寿限的方法并揭示其中的机理,本文对此作一综述.
|
| 关 键 词： | 哺乳动物雷帕霉素靶蛋白mTOR 核糖体SK蛋白激酶 衰老 |
| 收稿时间： | 2013/6/24 0:00:00 |
| 修稿时间： | 2013/9/26 0:00:00 |
mTOR and S6K Play an Important Role in Ageing |
| |
| ZHU Feng,MA Li-Wei and TONG Tan-Jun.mTOR and S6K Play an Important Role in Ageing[J].Progress In Biochemistry and Biophysics,2014,41(5):443-448. |
| |
| Authors: | ZHU Feng MA Li-Wei and TONG Tan-Jun |
| |
| Institution: | Research Center on Aging, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences,Peking University Health Science Center, Beijing 100191, China,Research Center on Aging, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences,Peking University Health Science Center, Beijing 100191, China and Research Center on Aging, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences,Peking University Health Science Center, Beijing 100191, China |
| |
| Abstract: | Aging process is modulated by various genes and signaling pathways. Mammalian target of rapamycin (mTOR) and ribosomal protein S6 kinase (S6K) not only regulate the physiological functions of cells, but also play an important role in the ageing progression. Recent study showed that inhibiting mTORC1 or S6K can extend the life span of mice. mTOR signaling influences ageing through various ways, including cell autophagy, metabolic by-products accumulation and affects the number of stem cells in tissues. However, the role of S6K in the ageing process remains unclear yet. Studies on the role of these two molecules in the ageing process, which have become a hotspot, are expected to find the method to extend the life span of mammalian and reveal its mechanisms. This review will focus on the role of mTOR and S6K in ageing. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
| 点击此处可从《生物化学与生物物理进展》下载免费的PDF全文 |
|
