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Epidemiological study on the relationship between toxin production and psm-mec mutations in MRSA isolates in Thailand |
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| Authors: | Fumiaki Tabuchi Aroonlug Lulitanond Viraphong Lulitanond Sudaluck Thunyaharn Chikara Kaito |
| Institution: | 1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan;2. Center for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand;3. Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;4. Faculty of Medical Technology, Nakhonratchasima College, Nakhon Ratchasima, Thailand
Department of Microbiology, Phramongkutklao College of Medicine, Bangkok, Thailand;5. Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan |
| Abstract: | In this present study, we investigated the phenol-soluble modulin (psm-mec) mutations, the staphylococcal cassette chromosome mec (SCCmec) types, and toxin production in 102 methicillin-resistant Staphylococcus aureus (MRSA) isolates from the northeast and central regions of Thailand. The MRSA isolates carrying -7T>C psm-mec in Type II SCCmec (n = 18) and the MRSA isolates carrying no psm-mec in Type IV (n = 8) or Type IX SCCmec (n = 4) had higher hemolytic activity against sheep erythrocytes than MRSA isolates carrying intact psm-mec in Type III SCCmec (n = 34), but MRSA isolates carrying no psm-mec in Type I SCCmec (n = 27) did not. |
| Keywords: | MRSA psm-mec SCCmec toxin virulence |