SNP-based heritability and genetic architecture of cranial cruciate ligament rupture in Labrador Retrievers |
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| Authors: | S R Cook M G Conzemius M E McCue K J Ekenstedt |
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| Institution: | 1. Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, 625 Harrison St, West Lafayette, IN, 47907 USA;2. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, 1352 Boyd Avenue, St Paul, MN, 55108 USA;3. Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Avenue, St Paul, MN, 55108 USA |
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| Abstract: | Cranial cruciate ligament rupture (CCLR) is one of the leading causes of pelvic limb lameness in dogs. About 6% of Labrador Retrievers suffer from this orthopedic problem. The aim of this study was to determine the heritability of CCLR in this breed using SNP array genotyping data. DNA samples were collected from CCLR-affected dogs (n = 190) and unaffected dogs over the age of 8 years (n = 143). All 333 dogs were genotyped directly or imputed up to approximately 710k SNPs on the Affymetrix Axiom CanineHD SNP array. Heritability of CCLR was calculated using multiple methodologies, including linear mixed models, Bayesian models and a model that incorporates LD. The covariates of sex and sterilization status were added to each analysis to assess their impact. Across the algorithms of these models, heritability ranged from 0.550 to 0.886, depending on covariate inclusion. The relatively high heritability for this disease indicates that a substantial genetic component contributes to CCLR in the Labrador Retriever. |
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| Keywords: | anterior cruciate ligament canine covariates dog heritability programs |
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