Meningitis and bacteremia by nonhemolytic Group B Streptococcus strain: A whole genome analysis |
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| Authors: | Akihiko Shimizu Hiroyuki Tsukagoshi Tsuyoshi Sekizuka Makoto Kuroda Aya Koizumi Masahiro Fujita Yoshiyuki Yamada Nobuhiro Saruki |
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| Affiliation: | 1. Department of Allergy, Infectious Diseases and Immunology, Gunma Children's Medical Center, Shibukawa, Gunma, Japan;2. Gunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, Gunma, Japan;3. Pathogen Genomics Center, National Institute of Infectious Diseases, Tokyo, Japan;4. Department of Neonatology, Gunma Children's Medical Center, Shibukawa, Gunma, Japan |
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| Abstract: | Group B streptococcus (GBS) is a leading cause of neonatal infections. Most isolates are β-hemolytic, and their activity is considered to be pivotal for GBS pathogenicity. We report a case of a neonate with meningitis caused by nonhemolytic GBS. The patient developed meningitis 3 days after birth. Genotyping was performed and the characteristics of the strain (GCMC97051) identified by whole genome sequence using next generation sequencing. GCMC97051 possesses genetic alterations such as disruption of cylA by IS1381A insertion and a frameshift mutation in cylE, resulting in a lack of hemolysis. Thus, nonhemolytic GBS can retain the potential to cause invasive infections. |
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| Keywords: | cylA meningitis nonhemolytic strain Streptococcus agalactiae |
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