Feline chimerism revealed by DNA profiling |
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Authors: | Ambre Jaraud Philippe Bossé Caroline Dufaure de Citres Laurent Tiret Vincent Gache Marie Abitbol |
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Affiliation: | 1. U955 – IMRB - Team 10 – Biology of the neuromuscular system, Inserm, UPEC, EFS , École nationale vétérinaire d’Alfort, Maisons-Alfort, France;2. Antagene, La Tour de Salvagny, France;3. Univ Lyon, Institut NeuroMyoGène, CNRS UMR5310, INSERM U1217, Faculté de Médecine Rockefeller, Université Claude Bernard Lyon I, Lyon, France |
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Abstract: | In dogs and cats, unusual coat colour phenotypes may result from various phenomena, including chimerism. In the domestic cat, the tortoiseshell coat colour that combines red and non-red hairs is the most obvious way to identify chimeras in males. Several cases of tortoiseshell males have been reported, some of which were diagnosed as chimeras without any molecular confirmation. Here, we report the case of a female feline chimera identified thanks to its coat colour and confirmed through DNA profiling and a coat colour test. We ruled out the hypothesis of mosaicism and aneuploidy. All the data were consistent with a natural case of female chimerism. |
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Keywords: | cat chimera coat colour dispermy DNA profile Felis catus microsatellite MLPH zygote |
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