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Evolutionary development and co-phylogeny of primate-associated bifidobacteria |
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| Authors: | Gabriele Andrea Lugli Giulia Alessandri Christian Milani Leonardo Mancabelli Lorena Ruiz Federico Fontana Santiago Borragán Andrea González Francesca Turroni Maria Cristina Ossiprandi Abelardo Margolles Douwe van Sinderen Marco Ventura |
| Institution: | 1. Laboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability, University of Parma, Parma, 43124 Italy;2. Department of Veterinary Medical Science, University of Parma, Parma, 43124 Italy;3. Laboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability, University of Parma, Parma, 43124 Italy
Microbiome Research Hub, University of Parma, Parma, 43124 Italy;4. Department of Microbiology and Biochemistry, Dairy Research Institute of Asturias, Spanish National Research Council (IPLA-CSIC), Paseo Río Linares s/n, Villaviciosa, Asturias, 33300 Spain MicroHealth Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, Spain;5. Parque de Cabárceno, 39690 Obregón, Cantabria, Spain;6. Zoo de Santillana, Avda. del Zoo 2, Santillana del Mar, Cantabria, 39330 Spain;7. APC Microbiome Institute and School of Microbiology, Bioscience Institute, National University of Ireland, T12 YT20, Cork, Ireland |
| Abstract: | In recent years, bifidobacterial populations in the gut of various monkey species have been assessed in several ecological surveys, unveiling a diverse, yet unexplored ecosystem harbouring novel species. In the current study, we investigated the species distribution of bifidobacteria present in 23 different species of primates, including human samples, by means of 16S rRNA microbial profiling and internal transcribed spacer bifidobacterial profiling. Based on the observed bifidobacterial-host co-phylogeny, we found a statistically significant correlation between the Hominidae family and particular bifidobacterial species isolated from humans, indicating phylosymbiosis between these lineages. Furthermore, phylogenetic and glycobiome analyses, based on 40 bifidobacterial species isolated from primates, revealed that members of the Bifidobacterium tissieri phylogenetic group, which are typical gut inhabitants of members of the Cebidae family, descend from an ancient ancestor with respect to other bifidobacterial taxa isolated from primates. |
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