Zinc,an unexpected integrator of metabolism? |
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Authors: | Antoine Danchin |
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Institution: | AMAbiotics SAS, Institut Cochin, 24 rue du Faubourg Saint-Jacques, 75014 Paris, France |
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Abstract: | Even when they no longer require the presence of iron, cells use zinc as a divalent cation, involved in a large variety of catalytic and regulatory functions. This metal is so important that it appears that ribosomes are instrumental in its ultimate storage. Here, we summarize a detailed analysis which investigates the way the global cell metabolism is integrated by zinc. This integration results from the zinc-dependent way in which the one-carbon metabolism is always coupled to the translation process, not only via methionine and S-adenosylmethionine, but via the complex set-up of the modification of the position 34 of the anticodon of tRNAs. |
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