Biosynthesis of acyl-specific glycerophospholipids in mammalian tissues. Postulation of new pathways |
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Authors: | J P Infante |
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Affiliation: | Division of Nutritional Sciences, N-209 MVR, Cornell University, Ithaca, NY 14853, USA |
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Abstract: | A review of the literature concerning the synthesis of acyl-specific glycerophospholipids indicates that the known biosynthetic sequences cannot satisfactorily explain these specific acylations . New de novo and salvage pathways are proposed to account for the acyl composition of highly unsaturated and saturated glycerophospholipids. In these hypothetical pathways, de novo synthesized glycerophosphodiesters are postulated to be key intermediates to establish the specific acyl composition of the resulting glycero-phospholipids, and to be integrated with the known cytidine pathways. A re-interpretation of the experimental literature in terms of these postulated pathways is provided, with some methods to test these proposed sequences. |
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Keywords: | GP, glycerophosphate P-choline, phosphorylcholine P-ethanolamine, phosphorylethanolamine CDP-choline, cytidinediphosphocholine CDP-ethanolamine, cytidinediphosphoethanolamine CDP-serine, cytidinediphosphoserine CDP-glycerol, cytidinediphosphoglycerol CDP-DG, cytidinediphosphodiglyceride GPC, glycerophosphorylcholine GPE, glycerophosphorylethanolamine GPG, glycerophosphorylglycerol GPS, glycerophosphorylserine PA, phosphatidic acid PC, phosphatidylcholine PE, phosphatidylethanolamine PG, phosphatidylglycerol PGP, phosphatidylglycerophosphate PGGP, phosphatidylglyceroglycerophosphate CL, cardiolipin PI, phosphatidylinositol PS, phosphatidylserine C18:0, octadecanoate |
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