Study of Antibacterial Activity of ZnZnbisporphyrin Complexes and its Free Components on <Emphasis Type="Italic">Staphylococcus aureus</Emphasis> by Microcalorimetry |
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| Authors: | Xiang-jiao Xu Chun-qiao Chen Zhuo-yuan Wang Yi Zhang An-xin Hou Chao-Hong Li Yi Liu |
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| Institution: | (1) State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072, China;(2) College of Chemical Engineering and Technology, Wuhan University of Science and Technology, Wuhan, Hubei, 430081, China;(3) School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, 430072, China |
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| Abstract: | The antibacterial effect of Zn(II), tetraphenyl porphyrin (TPP), propdioxyl bridged tetraphenyl bisporphyrin 1, and its metallobisporphyrin complexes (ZnMnbisporphyrin 2 and ZnZnbisporphyrin 3) towards Staphylococcus aureus growth was investigated by microcalorimetry at 37°C. Differences in their capacities to inhibit the growth metabolism of
S. aureus were observed. By analyzing the power–time curves, crucial parameters such as the rate constant of bacterial growth (k), inhibitory ratio (I), and generation time (t
G) were determined. The growth rate constant (k) of S. aureus (in the log phase) in the presence of the drugs decreased linearly with increasing concentrations of the complexes. The sequence
of the antibacterial activities of these compounds tested was 3 > 2 > 1 > Zn(II) > TPP. ZnZnbisporphyrin 3 is proposed to benefit from the synergetic effects of Zn(II) and 1. |
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| Keywords: | Bisporphyrin complexes Staphylococcus aureus Antibacterial effects Microcalorimetry Thermokinetics |
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