Design, synthesis and biological evaluation of novel bicyclic beta-lactams as potential antimalarials |
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| Authors: | Nivsarkar Manisha Thavaselvam D Prasanna S Sharma Mamta Kaushik M P |
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| Affiliation: | Process Technology Development Division, Defence R&D Establishment, Jhansi Road, Gwalior 474002, MP, India. |
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| Abstract: | A series of bicyclic N-substituted and unsubstituted beta-lactams were synthesized and evaluated as targeted potential antimalarials. The compounds MNR4 and MNR5 were found to have highest potency against Plasmodium falciparum in vitro. |
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