Metal complexes of luteinizing hormone-releasing hormone (LHRH). potentiometric and spectroscopic studies |
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Authors: | K Gerega H Kozlowski E Masiukiewicz L D Pettit S Pyburn B Rzeszotarska |
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Affiliation: | Institute of Chemistry, University of Wroclaw, Poland. |
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Abstract: | The results are reported of a potentiometric and spectroscopic study of the H+, Cu2+, and Ni2+ complexes of luteinizing hormone-releasing hormone (LHRH, HL) at 25 degrees C and an ionic strength 0.10 mol dm-3 (KNO3), since there is much evidence that the in vivo release of LHRH is influenced by the concentration of copper ions. With Cu2+ the hormone has been shown to behave similarly to the thyrotropin releasing factor, forming a very stable [CuH-1L] complex involving coordination of three nitrogen donors: the Nim atom of the imidazole side chain and the two amido-N atoms of the pyroglutamylhistidyl unit. With Ni2+, coordination proceeds differently to give four nitrogen coordination. |
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