| 细菌毒素-抗毒素系统的功能 |
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| 引用本文： | 何志利,王慧.细菌毒素-抗毒素系统的功能[J].生物工程学报,2018,34(8):1270-1278. |
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| 作者姓名： | 何志利 王慧 |
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| 作者单位： | 军事科学院军事医学研究院微生物流行病研究所病原微生物生物安全国家重点实验室 |
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| 基金项目： | 国家重点基础研究发展计划 (973计划) (No. 2015CB554202) 资助。 |
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| 摘 要： | 毒素-抗毒素(Toxin-Antitoxin,TA)系统广泛存在于原核生物和古细菌的染色体和质粒中。此系统由2个共表达的基因组成,分别编码稳定的毒素蛋白和易降解的抗毒素,毒素通常发挥毒性作用抑制细菌生长,而抗毒素则可中和毒性,二者相互作用对细菌生长状态起精密调节作用。根据TA的组成和抗毒素的性质,目前已经发现有6型TA,这些TA系统在细菌中发挥的作用一直是近年来学者们研究的热点,文中对细菌TA的功能研究进展进行了综述。
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| 关 键 词： | 毒素-抗毒素系统，环境适应性，持留态细胞，生物被膜，细菌毒力 |
| 收稿时间： | 2017/12/28 0:00:00 |
Functions of bacterial Toxin-Antitoxin systems |
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| Zhili He and Hui Wang.Functions of bacterial Toxin-Antitoxin systems[J].Chinese Journal of Biotechnology,2018,34(8):1270-1278. |
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| Authors: | Zhili He and Hui Wang |
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| Institution: | State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100071, China and State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100071, China |
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| Abstract: | TA (Toxin-Antitoxin) systems are widely spread in chromosomes and plasmids of bacteria and archaea. These systems consist of two co-expression genes, encoding stable toxin and sensitive antitoxin, respectively. The toxicity of toxins usually inhibits bacterial growth and antitoxins can neutralize the toxins. Interaction between them would regulate the growth state of bacteria precisely. According to the composition of TA and nature of antitoxin, six types of TA have been found. The role of these TA systems in bacteria has been a hot research topic in recent years. Now, the research status on functions of bacterial TA is reviewed. |
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| Keywords: | Toxin-Antitoxin system environmental adaptability persisters biofilm bacterial virulence |
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