Anti-inflammatory activity profile of JANEX-1 in preclinical animal models |
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Authors: | Uckun Fatih M Tibbles Heather Ozer Zahide Qazi Sanjive Vassilev Alexei |
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Affiliation: | Parker Hughes Cancer Center, 2848 Patton Road, St. Paul, MN 55113, USA. fatih_uckun@ih.org |
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Abstract: | We examined the biologic activity of the rationally designed JAK3 inhibitor, JANEX-1, in several cellular and animal models of inflammation. Notably, JANEX-1 exhibited potent anti-inflammatory activity in each of these preclinical models, including mouse models of peritonitis, colitis, cellulitis, and systemic inflammatory response syndrome. Therefore, JANEX-1 may prove useful as a broad-spectrum anti-inflammatory agent. The present study may provide the basis for new and effective treatment as well as prevention programs for inflammatory disorders. |
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