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Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors |
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| Authors: | Dai Yujia Hartandi Kresna Soni Niru B Pease Lori J Reuter David R Olson Amanda M Osterling Donald J Doktor Stella Z Albert Daniel H Bouska Jennifer J Glaser Keith B Marcotte Patrick A Stewart Kent D Davidsen Steven K Michaelides Michael R |
| Affiliation: | Cancer Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6100, USA. yujia.dai@abbott.com |
| Abstract: | Tumor angiogenesis is mediated by KDR and other VEGFR and PDGFR kinases. Their inhibition presents an attractive approach for developing anticancer therapeutics. Here, we report a series of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors. A number of compounds have been identified to be orally bioavailable and efficacious in the mouse edema model. |
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