| 工业微生物菌种改造的新方法——优势小基因组生产菌的构建 |
| |
| 引用本文： | Wang Y,Guo W,Song C. 工业微生物菌种改造的新方法——优势小基因组生产菌的构建[J]. 微生物学报, 2012, 52(3): 286-294 |
| |
| 作者姓名： | Wang Y Guo W Song C |
| |
| 作者单位： | 王媛媛 (南开大学分子微生物学与技术教育部重点实验室,天津30007l) ; 郭文斌 (南开大学分子微生物学与技术教育部重点实验室,天津30007l) ; 宋存江 (南开大学分子微生物学与技术教育部重点实验室,天津30007l) ; |
| |
| 基金项目： | 国家“973项目”——国家重点基础研究发展计划(2012CB725204);国家自然科学基金(31070039,31170030,51073081)~~ |
| |
| 摘 要： | 本文介绍了构建优势小基因组生产菌株的必要性和可行性;介绍了优势小基因组工业微生物的构建原理和方法;同时,还介绍了几个目前已成功应用的通过基因组精简提高生产效率的例证;最后,结合作者的研究对优势小基因组生产菌的应用进行了展望。
|
| 关 键 词： | 菌种改造 必需基因 基因组精简 |
New method for industrial microbial strains improvement--construction of dominant genome-simplified strains--a review |
| |
| Wang Yuanyuan,Guo Wenbin,Song Cunjiang. New method for industrial microbial strains improvement--construction of dominant genome-simplified strains--a review[J]. Acta microbiologica Sinica, 2012, 52(3): 286-294 |
| |
| Authors: | Wang Yuanyuan Guo Wenbin Song Cunjiang |
| |
| Affiliation: | Key Laboratory of Molecular Microbiology and Technology for Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China. wyy2589@163.com |
| |
| Abstract: | The necessity and feasibility of constructing dominant genome-simplified strains for industrial production were introduced, based on some successful cases in which the production efficiency was improved after simplifying the genome of strains. The principle and process of genome simplifying were summarized. In addition, the perspective of dominant genome-simplified strains for industrial production was discussed, combined with authors' own studies. |
| |
| Keywords: | strain improvement essential gene genome simplifying |
| 本文献已被 CNKI PubMed 等数据库收录！ |
