Turning in MFB-lesioned rats and antagonism of neuroleptic-induced catalepsy after lisuride and LSD. |
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Authors: | M Pieri R Schaffner L Pieri M Da Prada W Haefely |
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Institution: | F. Hoffmann-La Roche & Co., Ltd Pharmaceutical Research Department, 4002 Basle/Switzerland |
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Abstract: | The effects of lisuride, d-lysergic acid diethyl amide (LSD) and apomorphine were studied in rats with unilateral destruction of nigro-striatal nerve terminals either with 6-hydroxydopamine (6-OHDA) or 5, 6-dihydroxytryptamine (5,6-DHT). Lisuride at the dose of 50 μg kg?1 i.p. induced contralateral turning for more than 4 hours while the circling induced by LSD (200 μg kg?1) and apomorphine (1 mg kg?1) persisted for only one hour. Lisuride, a compound stimulating both dopamine (DA) and 5-hydroxytryptamine (5-HT) receptors induced a more intense turning in 6-OHDA than in 5,6-DHT lesioned rats. This might indicate a modulation of 5-HT on rotational behavior. Haloperidol (1 mg kg?1 i.p.) antagonized both lisuride- and LSD-induced turning. LSD, and much more persistently lisuride, counteracted the prochlorperazine-induced catalepsy. These findings correlate with the biochemical data indicating that lisuride is a very potent agonist at central dopaminergic receptors. |
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