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Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists |
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| Authors: | Xin Zhili Zhao Hongyu Serby Michael D Liu Bo Schaefer Verlyn G Falls Douglas H Kaszubska Wiweka Colins Christine A Sham Hing L Liu Gang |
| Affiliation: | Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. zhili.xin@abbott.com |
| Abstract: | A series of isoxazole carboxamide derivatives has been developed as potent ghrelin receptor antagonists. The synthesis and structure-activity relationship (SAR) are described. |
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