Enzyme kinetics: Inhibition equations derived from the inelastic collision hypothesis

The inelastic collision hypothesis of enzyme action has been proposed by G. Medwedew. This theory has been here extended to the cases of competitive and non-competitive inhibitors, which form enzyme-inhibitor complexes, and to the cases of competitive and non-competitive substrates. The resulting equations are discussed and contrasted to those derived from the classical enzyme-substrate hypothesis. The original formulation of Medwedew neglects the presence of the enzyme-substrate complex although the general theory admits the formation of this complex. The formulation has been revised and extended to include complex formation. The resulting equation is discussed in terms of the usual criteria used to evaluate the Michaelis-Menten-Briggs-Haldane equation. Taken in part from a thesis submitted by Robert Katzman to the faculty of the Department of Physiology, University of Chicago, in partial fulfillment of the requirements for the Degree of Master of Science.