On the Origin of Operons and Their Possible Role in Evolution Toward Thermophily |
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Authors: | Nicolas Glansdorff |
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Institution: | (1) Microbiology, Vrije Universiteit Brussel, Research Institute of the CERIA-COOVI, and Department of Microbiology of the Flanders Interuniversity Institute of Biotechnology, E. Grysonlaan 1, B1070-Brussels, Belgium, BE |
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Abstract: | We present a hypothesis suggesting that close linkage of functionally related anabolic genes and their ultimate integration
into operons developed under selective pressure as a molecular strategy which contributed to the viability of ancestral thermophilic
cells. Cotranslation of functionally related proteins is viewed as having facilitated the formation of multienzyme complexes
channeling thermolabile substrates and the mutual stabilization of inherently thermolabile proteins. In this perspective,
the evolutionary scheme considered the most probable is the evolution of both Bacteria and Archaea by thermoreduction (Forterre
1995) from a mesophilic, protoeukaryotic last common ancestor (LCA) endowed with appreciable genetic redundancy. |
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Keywords: | : Operons — Thermophily — Last common ancestor |
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