The role of physiologically based toxicokinetic models in biologically based risk assessment |
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| Authors: | Watanabe K H Chen C |
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| Institution: | Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana 70112, USA. |
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| Abstract: | Biologically-based cancer risk assessment relies on mathematical models that represent the toxicokinetics and toxicodynamics of the xenobiotic in the body. Physiologically-based toxicokinetic (PBTK) models are used as a tool for predicting the target tissue dose of a xenobiotic from different routes of exposure, extrapolating from high doses to low doses and extrapolating between species. This paper reviews the role of PBTK models and their limitations in biologically-based risk assessment. |
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