LRP 1 B functions as a receptor for Pseudomonas exotoxin |
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| Authors: | Pastrana Diana V Hanson Alison J Knisely Jane Bu Guojun Fitzgerald David J |
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| Institution: | Laboratory of Molecular Biology, CCR, National Cancer Institute, Bethesda, MD 20892-4263, USA. |
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| Abstract: | Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors, among them Pseudomonas Exotoxin A (PE). Previously, low-density lipoprotein receptor-related protein 1 (LRP 1) was shown to be the primary receptor for PE. In this report, we show that a close family member, LRP 1B, can also function as a receptor. |
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