Effects of diabetes type and treatment on zinc status in diabetes mellitus |
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Authors: | Jerome Honnorat Michele Accominotti Christiane Broussolle Andree-Carole Fleuret Jean-Jacques Vallon Jacques Orgiazzi |
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Affiliation: | 1. Service de Médecine Interne, Centre Hospitalier Lyon-Sud, 69310, Pierre Benite, France 2. Laboratoire Pharmaceutique de Biochimie, Toxicologie et Analyse des Traces, H?pital Edouard Herriot, 69003, Lyon, France
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Abstract: | Zinc status was assessed in 53 diabetic patients: 18 insulin-dependent diabetic patients (IDDM), 22 noninsulin-dependent diabetic patients (NIDDM) treated with oral antidiabetic agents, and 13 insulin-treated, noninsulin-dependent diabetic patients (IRDM). Plasma zinc concentrations were in the usual range for healthy subjects in these three groups (15.3±0.9 μmol/L). Urinary zinc excretions were elevated in the IDDM group (18.3±4.1 μmol/24 h;p<0.01 vs normal) and in the NIDDM group (17.5±3.5 μmol/24 h;p<0.01 vs normal), but normal in the IRDM group (11.3±2.4 μmol/24 h). In 14 NIDDM patients treated with transient continuous sc insulin injections, urinary zinc decreased from 16.5±2.2 μmol/24 h before insulin treatment to 11.5±0.3 μmol/24 h after insulin treatment without any modification in plasma zinc concentrations. |
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Keywords: | Zinc diabetes mellitus insulin treatment oral antidiabetic agents |
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