Important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against cisplatin-induced nephrotoxicity in LLC-PK1 cells |
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Authors: | Ji Hwan Lee Woojung Lee Seungyong Lee Yujung Jung Soon-Hye Park Pilju Choi Su-Nam Kim Jungyeob Ham Ki Sung Kang |
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Affiliation: | Natural Medicine Center, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea. |
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Abstract: | The aim of the present study was to verify the important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against oxidative stress-induced nephrotoxicity. The free radical-scavenging activity of ginsenoside Re-serine mixture was increased by heat-processing. Ginsenoside Re was transformed into less-polar ginsenosides such as Rg(2), Rg(6) and F(4) by heat-processing, and the glucose molecule at carbon-20 was separated. The improved-free radical-scavenging activity by heat-processing was mediated by the generation of antioxidant Maillard reaction products (MRPs) from the reaction of glucose with serine. Moreover, MRPs from ginsenoside Re-serine mixture showed protective effect against cisplatin-induced renal epithelial cell damage. |
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