| 人白介素6受体结合功能域的构效关系研究 |
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| 引用本文： | 冯健男,任蕴芳,李松,沈倍奋.人白介素6受体结合功能域的构效关系研究[J].生物化学与生物物理进展,2000,27(1):53-57. |
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| 作者姓名： | 冯健男 任蕴芳 李松 沈倍奋 |
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| 作者单位： | 1. 军事医学科学院基础医学研究所,北京,100850
2. 军事医学科学院药物毒物研究所,北京,100850 |
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| 基金项目： | 国家自然科学基金资助项目(39480025). |
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| 摘 要： | 以分子对接（docking）方法研究人白介素6受体胞外区配基结合功能域“WSXWS”区氨基酸残基定点突变对受体与配基人白介素6结合时的相互作用能量、分子间相互作用的影响，从分子力学、分子动态学分析了人白介素6受体胞外区功能域关键氨基酸残基在受体与配基结合中的构象变化以及与人白介素6间的相互作用.
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| 关 键 词： | 人白介素6受体，人白介素6，分子对接，功能域 |
| 收稿时间： | 1998/11/5 0:00:00 |
| 修稿时间： | 2/8/1999 12:00:00 AM |
The Structure and Activity Studies Based on Combining Functional Domain of Human Interleukin-6 Receptor |
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| FENG Jian-Nan,REN Yun-Fang,LI Song and SHEN Bei-Fen.The Structure and Activity Studies Based on Combining Functional Domain of Human Interleukin-6 Receptor[J].Progress In Biochemistry and Biophysics,2000,27(1):53-57. |
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| Authors: | FENG Jian-Nan REN Yun-Fang LI Song and SHEN Bei-Fen |
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| Institution: | Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China;Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China;Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China;Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract: | |
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| Keywords: | human interleukin-6 receptor(hIL-6R) human interleukin-6(hIL-6) molecular docking functional domain |
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