|
|||||
|
|
The non-proteinogenic amino acids l-methionine sulfoximine and dl-phosphinothricin activate mTOR |
|
| Authors: | Saverio Tardito Martina Chiu Renata Franchi-Gazzola Valeria Dall’Asta Paola Comi Ovidio Bussolati |
| Affiliation: | 1. Unit of General and Clinical Pathology, Department of Experimental Medicine, University of Parma, Via Volturno 39, 43125, Parma, Italy 2. Doctorate School of Molecular Medicine, University of Milan, Milan, Italy 3. Department of Medicine, Surgery and Dentistry, H. S. Paolo, University of Milan, Milan, Italy |
| Abstract: | l-Methionine sulfoximine (MSO) and dl-Phosphinothricin (PPT), two non-proteinogenic amino acids known as inhibitors of Glutamine Synthetase, cause a dose-dependent increase in the phosphorylation of the mTOR substrate S6 kinase 1. The effect is particularly evident in glutamine-depleted cells, where mTOR activity is very low, but is detectable for PPT also in the presence of glutamine. The stimulation of mTOR activity by either MSO or PPT is strongly synergized by essential amino acids. Thus, the non-proteinogenic amino acids MSO and PPT are mTOR activators. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |