Sensitive and Label-Free Detection of DNA by Surface Plasmon Resonance |
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| Authors: | Yong-Jun Li Juan Xiang Feimeng Zhou |
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| Affiliation: | (1) Department of Chemistry and Biochemistry, California State University, Los Angeles, CA 90032, USA;(2) Institute of Surface Analysis and Biosensing, School of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, People’s Republic of China |
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| Abstract: | While an array of technologies based on radioactive labels or luminescent tags are dominant in modern biomedical research on DNA, surface plasmon resonance (SPR) and SPR imaging measurements are sensitive, rapid, and label-free. This review summarizes recent advances in the development of SPR and coupled techniques and their applications in DNA research, including the gene analysis at trace levels and studies of DNA–protein and DNA–drug interactions. |
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| Keywords: | Surface plasmon resonance Surface plasmon resonance imaging DNA DNA– protein interaction DNA– drug interaction |
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