Synthesis and surface activity of diether-linked phosphoglycerols: potential applications for exogenous lung surfactants |
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Authors: | Notter Robert H Wang Zhongyi Wang Zhengdong Davy Jason A Schwan Adrian L |
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Affiliation: | Department of Pediatrics, University of Rochester, Rochester, NY 14642, USA. |
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Abstract: | The synthesis of three phosphoglycerols is described, one of which contains the previously unknown phosphonoglycerol headgroup. The surface tension-lowering capabilities of synthetic lung surfactant mixtures containing the PG analogs were measured on the pulsating bubble surfactometer and compared to known controls. The PG-containing mixtures exhibited superior surface tension-lowering properties indicating the significant potential of these analogs as components in synthetic exogenous lung surfactants. |
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