Deciphering the model pathogenic fungus Cryptococcus neoformans |
| |
Authors: | Idnurm Alexander Bahn Yong-Sun Nielsen Kirsten Lin Xiaorong Fraser James A Heitman Joseph |
| |
Institution: | Department of Molecular Genetics and Microbiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA. |
| |
Abstract: | Cryptococcus neoformans is a basidiomycete fungal pathogen of humans that has diverged considerably from other model fungi such as Neurospora crassa, Aspergillus nidulans, Saccharomyces cerevisiae and the common human fungal pathogen Candida albicans. The recent completion of the genome sequences of two related C. neoformans strains and the ongoing genome sequencing of three other divergent Cryptococcus strains with different virulence phenotypes and environmental distributions should improve our understanding of this important pathogen. We discuss the biology of C. neoformans in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|