| 综述: 整合素相关微环境调控肿瘤转移 |
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| 引用本文： | 李雪映,孙小然,张宏权.综述: 整合素相关微环境调控肿瘤转移[J].生物化学与生物物理进展,2017,44(8):672-677. |
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| 作者姓名： | 李雪映 孙小然 张宏权 |
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| 作者单位： | 北京大学医学部，北京 100191,北京大学医学部，北京 100191,北京大学医学部，北京 100191 |
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| 基金项目： | 国家自然科学基金重点项目资助项目(81230051) |
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| 摘 要： | 整合素是肿瘤微环境的重要组成部分，是广泛存在于细胞膜表面的黏附分子，可以识别并结合细胞外基质中相应的配体，参与许多重要的生理过程，包括肿瘤转移．整合素可以促进肿瘤转移的各个阶段，肿瘤微环境也会反过来影响整合素的表达，从而促进癌症的发生发展．
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| 关 键 词： | 整合素，肿瘤微环境，肿瘤转移 |
| 收稿时间： | 2017/7/10 0:00:00 |
| 修稿时间： | 2017/7/10 0:00:00 |
Review: Integrin-related Tumor Microenvironment Regulates Tumor Metastasis |
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| LI Xue-Ying,SUN Xiao-Ran and ZHANG Hong-Quan.Review: Integrin-related Tumor Microenvironment Regulates Tumor Metastasis[J].Progress In Biochemistry and Biophysics,2017,44(8):672-677. |
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| Authors: | LI Xue-Ying SUN Xiao-Ran and ZHANG Hong-Quan |
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| Institution: | Peking University Health Science Center, Beijing 100191, China,Peking University Health Science Center, Beijing 100191, China and Peking University Health Science Center, Beijing 100191, China |
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| Abstract: | Integrins are important components of tumor microenvironment, which act as adhesion molecules located on cell surface. Integrins can recognize and interact with different ligands in order to participate in many important physiological processes, including tumor cell invasion and metastasis. Integrin activation mediates tumor cell metastasis, and reversely tumor microenvironment can influence the expression and activation of integrin, and thus promotes tumor progression. |
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