Nitric oxide acts as a retrograde messenger during long-term potentiation in cultured hippocampal neurons |
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| Authors: | O Arancio V Lev-Ram R Y Tsien E R Kandel R D Hawkins |
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| Institution: | 1. Center for Neurobiology and Behavior, Columbia University, 722 W 168th Street, New York, NY 10032, USA;2. New York State Psychiatric Institute, 722 W 168th Street, New York, NY 10032, USA;3. Howard Hughes Medical Institute, 722 W 168th Street, New York, NY 10032 USA;4. Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA;5. Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093, USA |
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| Abstract: | We examined long-term potentiation (LTP) at synapses between hippocampal neurons in dissociated cell culture following presynaptic, postsynaptic, or extracellular application of a nitric oxide (NO) scavenger, an inhibitor of NO synthase, and a membrane-impermeant NO donor that releases NO only upon photolysis with UV light. Our results indicate that NO is produced in the postsynaptic neuron, travels through the extracellular space, and acts directly in the presynaptic neuron to produce long-term potentiation, supporting the hypothesis that NO acts a retrograde messenger during LTP. |
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| Keywords: | long-term potentiation (LTP) nitric oxide retrograde messenger photolytic release |
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