2,3,7,8-Tetrachlorodibenzo-P-dioxin: potent anticarcinogenic activity in CD-1 mice. |
| |
Authors: | J DiGiovanni D L Berry M R Juchau T J Slaga |
| |
Affiliation: | 1. Department of Pharmacology, School of Medicine, University of Washington, Seattle, WA. 98195 USA;2. Biology Division, Oak Ridge National Laboratory, Oak Ridge, TN. 37830 USA |
| |
Abstract: | Topical pretreatment with non-toxic doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a contaminant formed in the commercial synthesis of the herbicide 2,4,5-trichlorophen-oxyacetic acid, strongly inhibited the initiation of skin tumors by 7,12-dimethylbenz(a)-anthracene and benzo(a)pyrene in female CD-1 mice. 2,3,7,8-tetrachlorodibenzo-p-dioxin also produced marked induction of epidermal monooxygenase enzymes functional in the conversion of 7,12-dimethylbenz(a)anthracene to a variety of hydroxylated products. The time course of anticarcinogenic effects resulting from pretreatment with the dioxin correlated with the magnitude of induction as well as with a singnificant reduction in the quantity of 7,12-dimethylbenz(a)anthracene metabolites covalently bound to epidermal DNA and RNA but not protein. |
| |
Keywords: | Present address and to whom reprint requests should be addressed: McArdle Laboratory for Cancer Research University of Wisconsin Medical Center Madison WI. 53706. |
本文献已被 ScienceDirect 等数据库收录! |
|