Hematopoietic growth factors in autologous transplantation |
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Authors: | Gian Carlo Avanzi Margherita Gallicchio Giuseppe Saglio |
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Affiliation: | (1) Medical Clinic, Dept. of Medical Science, University of Turin, Novara, Italy;(2) Medical Clinic, Dept. of Biomedical Science and Human Oncology, University of Turin, Novara, Italy |
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Abstract: | Hematopoietic growth factors (HGFs) sustain the survival, proliferation and differentiation of hematopoietic stem cells and some functions of mature blood cells. In man several HGFs have been characterised and cloned so far, and this has allowed investigators to confer the rationale for the clinical application of these molecules in hematology and oncology. In particular G-CSF and GM-CSF are currently utilised to abrogate the hematological toxicity of chemotherapy for standard and dose-intensified therapy, neutropenia following bone marrow and peripheral blood stem cell transplantation. Moreover there has recently been great interest in the ex vivo expansion of hematopoietic stem and progenitor cells for a variety of applications, such as in vitro tumor cell purging or for reducing the volume of blood processed by the leukapheresis. Several combinations of HGFs have been described to sustain the ex vivo survival and proliferation of these cells disclosing new opportunities in the field of stem cells transplants. |
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Keywords: | hematopoietic growth factors bone marrow transplantation peripheral blood progenitor cells transplantation granulocyte colony-stimulating factor granulocyte-monocyte colony-stimulating factor hematopoietic stem cells |
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