| Abstract: | Study of the effects of acetylcholine, exogenous cGMP and Con A on the mobility of B lymphocytes has demonstrated that an increase in both the content of cGMP and calcium in B lymphocytes stimulates their mobility. The measurement of intracellular content of cGMP in B lymphocytes by radioimmunoassay has shown that this content changes rapidly in response to the action of acetylcholine and that it is dependent but negligibly on extracellular calcium. The dependence of the effects of all three substances on trifluoperazine, a calmodulin v blocker, indicates that stimulation of B lymphocyte mobility is ultimately determined by the calcium mechanisms. |
