Simple synthesis of novel acyclic (e)-bromovinyl nucleosides as potential antiviral agents |
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Authors: | Kim Jin Woo Hong Joon Hee |
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Institution: | College of Pharmacy, Chosun University, Kwangju, Republic of Korea. |
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Abstract: | In these study, novel acyclic (E)-bromovinyl nucleosides were synthesized as potential antiviral agents. The coupling of the allylic bromide 9 with bases (thymine, uracil, 5-fluorouracil, 5-iodouracil, cytosine, adenine) afforded a series of novel acyclic nucleosides. The synthesized compounds were evaluated for their antiviral activity against various viruses such as HIV-1, HSV-1, HSV-2, and HCMV. 5-Iodouracil analogue 19 showed weak anti-HIV-1 activity. |
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