Progesterone interaction with estrogen and antiestrogen in the rat uterus--receptor effects. |
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Authors: | Y Koseki D T Zava G C Chamness W L McGuire |
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Affiliation: | Departments of Obstetrics and Gynecology and of Medicine University of Texas Health Science Center San Antonio, Texas 78284 U.S.A. |
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Abstract: | Daily injections of estradiol or the antiestrogen tamoxifen initially stimulate uterine weight increase and progesterone receptor synthesis, though continued tamoxifen fails to maintain the increased weight. The stimulatory actions of both estradiol and tamoxifen are inhibited or reversed by a single injection of progesterone. It has been hypothesized that progesterone antagonizes estrogen action by reducing estrogen receptor levels, but in the present experiments neither cytoplasmic nor nuclear estrogen receptor was affected. We conclude that progesterone acts at a point beyond estrogen receptor availability or translocation to antagonize estrogen action. |
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Keywords: | Address reprint requests to W.L. McGuire M.D. Department of Medicine University of Texas Health Science Center 7703 Floyd Curl Drive San Antonio Texas 78284. |
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